There's no doubt the set of ABC's
Grey's Anatomy is basically an incubator for acting talent. Actors such as Ellen Pompeo, Katherine Heigl, and Sandra Oh became household names thanks to their roles on the hit medical drama. But it's not just the regular cast, who fans will instantly be able to recognize; there have also been a ton of who bring even more star power to the small screen, and they show up in episodes pretty often. Grey's Anatomy celebrity guest stars Grey's seems to be one of the stops many actors take on their way to stardom in the entertainment industry. Many of the talent listed below got their role on the medical drama before they hit "big time" fame in other roles later in their careers. For already established actors, a Grey's cameo also seems a bit like a bucket list item, as there also many celebs who've appeared on Grey's after they're already well-known for other roles.
In 16 seasons of
Grey's, there are plenty of episodes out there that feature celebrity guests — some of which fans may have missed the first time watching the series. So, take another look at these episodes to revisit your fave guest-star moment, and rediscover some surprise cameos.
The lead of Hulu's
The Handmaid's Tale once starred in Season 3, Episode 19 as Nina Rogerson, a concerned daughter of a patient needing high-risk surgery.
Moore played Mary Portman
, a recurring character in Seasons 6 and 7 of Grey's. Her character was in the hospital for a surgery when it was shut down due to an active shooter. She came back to the hospital six months later for the surgery, but ended up in a coma and eventually died.
Ricci starred in the two-part finale of
Grey's Season 2, in which she played a paramedic involved in a potential bomb situation.
Breslin starred in Season 3, Episode 3, as a young girl who couldn't feel pain.
Lowes played a blood donor in Season 7, Episode 22 of
Grey's. Fans may also know her for her role as Quinn Perkins in ABC's Scandal. Shonda Rhimes is the creator behind both shows, so it makes sense she'd use the same actors in some of her projects. Foley played Henry Burton in 15 episodes throughout Seasons 7 and 8 of Grey's. He first came into the hospital as an uninsured patient, but marries Teddy to get on her insurance and get his care. But just as soon as they were developing a real romance, Henry died because of a tumor. Foley has also had a long running role as Jake Ballard on Scandal.
Young is another
Scandal actor who made an appearance on Grey's. She played Kathy in Season 3, Episodes 22 and 23 — Private Practice crossover episodes. Her character sought help with sex in her relationship.
13 Reasons Why, Minnette played Ryan, a boy needed constructive ear surgery, in Season 4, Episode 5 of Grey's.
Daniels may be well known for his role as Mr. Feeney on
Boy Meets World, but on . His character was a cardiothoracic surgeon at the Mayo Clinic and a mentor of Cristina Yang's. He starred in five episodes throughout Seasons 8 and 9 of the medical drama. Grey's, he played Dr. Craig Thomas Morrison played Paul Stadler on Grey's, a well-known surgeon, but also the estranged, abusive husband of Jo. He starred in four episodes throughout Seasons 13 and 14 of the medical series. Morrison is also well-known for his role as Will Schuester on Glee.
Chung played Trina Paiz in Season 7, Episode 10 of
Grey's. Her character came into the hospital after falling over 100 feet into a ravine and suffering an ear injury.
Brosnahan may now be best known for her role as Midge Maisel in Amazon Prime Video's
The Marvelous Mrs. Maisel, but before that role, she was in Season 9, Episode 14 of Grey's.
Valderrama famously played Fez in
That '70s Show . On Grey's, he played Kyle Diaz, a musician with multiple sclerosis. His character died after five episodes in Season 12.
Milano played Haylee Peterson in Season 16, Episode 3 of
Grey's. Her character was the sister of someone who had fallen into a construction site and became brain-dead as a result. Twilight fans' favorite undead mom, Esme Cullen, was played by Reaser from 2009 to 2013. Before that role, though, she played Rebecca Pope in Seasons 3 and 4 of Grey's. Her character suffered brain damage and memory loss after a ferry accident, and bonded with Alex Karev while in the hospital. Eventually, she recovered her memories and tried to pursue a real relationship with him, but things did not work out. Birds of Prey actor Smollett-Bell played Beth Monroe, a patient with a tumor that left her partially paralyzed. Her character appeared in Episodes 16 and 17 of Season 4.
Fans may recognize Elizondo for his role as Joe the driver in
The Princess Diaries movies, but he also played Carlos Torres, Callie Torres' dad, in five episodes (over Seasons 3, 5, 6, 7 and 10).