Sam Simon passed away at the age of 59 after his lengthy battle with colon cancer.
Simon was best known as a co-creator of "The Simpsons," the longest running American sitcom of all time.
He died at his home in Los Angeles in the company of his family and his beloved dog.
Simon was a major animal rights advocate. During his life, he donated a great deal of money to PETA and went so far as to personally save mistreated animals.
Prior to his death, Simon announced he would leave the bulk of his $100 million fortune to charities.
The Sam Simon Foundation told TMZ,
Our thoughts are with Simon's family and friends. May he rest in peace.